... DNA-bindingand dimerization domain at their C-terminus, and a lessconserved proline-rich and glutamine-rich transactiva-tion domain at their N-terminus [8–10]. Most isoformsalso have a PY-motif ... Multiple alignment of AP-2a, AP-2b, AP-2c, AP-2d, and AP-2e. The proline-rich and glutamine-rich N-terminus, which is important for transactivation, is shown in yellow, and contains the PY-motif (green). ... aSTAT binding site is required for robust AP-2a expres-sion in the face and limbs. In a follow-up study, theyfound that this conserved cis-acting sequence serves tomaintain a level of AP-2a expression...