Tài liệu Báo cáo " The meaning and structure of a science fiction story: a sysyemic functional analysis " doc

... spaceship. There are two astronauts’ helmets, one in front of them and the other at their back. They are holding a fruit in their hands. The woman is looking at the man. The meaning and structure of ... declarative declarative declarative declarative declarative declarative declarative declarative declarative declarative declarative declarative declarative declarative declarative ... 18. astronauts 20. astronauts 21. they 13. man 23. the man 26. the man 26. the man anaphoric exophoric cataphoric anaphoric anaphoric anaphoric cataphoric anaphoric anaphoric...

Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... bound to the metal, in the company of a water oxygen, from the apical positions. The manga-nese was only 0.06 A ˚out of the equatorial plane(Table 3). The angles around the metal cofactor sug-gested ... Torikai1,2, Koichi Uegaki1, Junji Morita2, Kodai Machida3,4,Atsushi Suzuki5 and Yasushi Kawata3,41 National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan2 ... trigonal bipyramidal coordination with ﬁve ligands: four sidechain atoms and a water oxygen. One aspartate and two histidine sidechains ligated to the central metal on the equatorial plane. In the...

Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

... cycles of NOE assignment and structure calculation by cyana⁄ candid, a set of 20 structures thatsatisfy the experimental constraints was obtained. The Solution structure of hirsutellin A A. Viegas ... delPozo A & Gavilanes JG (2001) RNase U2 and alpha-sarcin: a study of relationships. Meth Enzymol 341,335–351.3 Lacadena J, A ´lvarez-Garcı´ a E, Carreras-Sangra N,Herrero-Gala´n E, Alegre-Cebollada ... buried,with the accessible surface area of the correspondingside chains very low. Desolvation of the chargedgroups should affect their pK a values, increasing the pK a of carboxylates and decreasing the...

Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... Biis the B factor of atom i, ljis the mean B factor (excluding water molecules and peptide atoms) and rjis the standard deviation of Bfactors. The normalized B factors have a zero mean and ... as the major and minor binding sites [1]. These sites arelocated in the concave face of the protein near regions of invariant Trp and Asn arrays. The major bindingsite spans ARM repeats 2, 3 and ... by the importin -a nuclear import pathway, provided that CLIC4 can undergo a conforma-tional rearrangement that exposes the NLS in an extended conformation.DatabaseStructural data are available...

Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

... phytate with pH optima in the acidic range. They consist of two domains, a large a ⁄ bdomain and a small a domain with the catalytic site at the interface of the two domains [4,5]. HAPs can initi-ate ... substrate-freeAppA the C a atoms are 2.41 A ˚apart, whereas for the substrate-free PhyK and the substrate-loaded AppA the averaged distance is only 1.87 A ˚.Distinct conformational changes ... similarity, the overall structure of Klebsiella phytase bears similar-ity to other histidine-acid phosphatases, such as E. coli phytase, glucose-1-phosphatase and human prostatic-acid phosphatase....

Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx

... extracellular matrix, it seems more likely that the SEA domain functions by orienting the active site cleft of DESC1 toward plasma and ⁄ or extracellular spaces and away from the cell surface and ⁄ or the ... Marathon-Ready cDNA (Clontech, Moun-tain View, CA, USA). Two fragments were isolated and conﬁrmed by Southern analysis using the internal cDNAfragment as the probe and by DNA sequence analysis. The cDNA ... regions of these proteinases medi-ate interaction of the two b-barrels, formation of the catalytic machinery and structures required for binding of the main chain of the substrate peptide and properpositioning...

Tài liệu Báo cáo khoa học: Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus doc

... Ivanova N, Sorokin A, Anderson I, Galleron N,Candelon B, Kapatral V, Bhattacharyya A, Reznik G,Mikhailova N, Lapidus A et al. (2003) Genomesequence of Bacillus cereus and comparative analysis with ... a6 ) and a C-terminal strand (b8). Helix a5 and strand b7 partially cover one side of the Ross-mann fold structure, thereby interacting with helices a1 , a2 and strand b5, respectively. The a5 -helix ... for the correct spatial arrangement of catalytically importantresidues to generate a functional active site. On the other hand, the low degree of conservation in the loopregions near the active...

Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc

... indole-3-acetic acid (IAA), which is synthe-sized by plants [1,2] and plant-associated bacteria [3,4].Several pathways for the synthesis of IAA in theseorganisms have been described, and most of them ... protein atoms. The ﬁnal R-values and other reﬁnement statistics are given in Table 1. The X-ray data and the atomic coordinates have been depositedat the Protein Data Bank, accession number 1ovm. Structure ... conformational transitions are accompanied bylarge-scalechangesintherelativeorientationofthedimersin the tetramer. In the three-dimensional structure of ZmPDC,theactivesiteloopsarewellorderedandobserved...

Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx

... boundto the mAb Fab131Andreas G. Tzakos1, Alexandre M. J. J. Bonvin2, Anasstasios Troganis3, Paul Cordopatis4, Mario L. Amzel5,Ioannis P. Gerothanassis1 and Nico A. J. van Nuland21Department ... interactions, there are threegeneral approaches that can be utilized to extract structuralinformation [4]: a peptide (ligand)-based approach, a receptor-based approach, and approaches that target the ligand–receptor ... 0.05 A ˚ and for all the heavyatoms (C a ,N,C¢, O) the RMSD is 0.32 ± 0.15 A ˚ .The RMSD values of the backbone atoms from the mean valuefor the 4–7 fragment is 0.10 ± 0.04 A ˚ and for all heavyatoms...

Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt

... exhibiting a three-stranded antiparallel b-sheet and an a- helix a 1.We show that the C-terminal portion of MAR-BD alsocontains an amphipathic helical coil, a 2 /a 3. The hydrophilicresidues of this ... Ramachandran plotshows that the dihedral angles / and w for the secondary structure elements are all found in the most favored or the additionally allowed region. A selected example of the 10structures ... analysis NMR data were analysed and processed with the computerprogramsXWINNMR,AURELIA[22], and AUREMOL[23](Bruker, Karlsruhe, Germany). In the ﬁnal part of the assignment of the NOESY spectra, the...

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