the expression of collagen degrading proteases involved in dupuytren s disease fibroblast mediated contraction
báo cáo hóa học: " The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice" pptx
... GFAP expression has been found to be increased following toxic insult to the CNS in many studies A single subcutaneous injection (50 μg/kg bw, 1/2 LD50) of the cholinesterase inhibitor Sarin was ... [17,18] In the present study, GFAP expression was increased in the groups receiving combined treatments of stress and CPF 0.2 dosage as compared to those just receiving CPF 0.2 dosage, but the increase ... plotted against each other This was done to facilitate regression analysis of the data Using the standard curve, serum concentrations of cholinesterase from the samples of different groups were then...
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Báo cáo khoa học: "Gamma-ray irradiation stimulates the expression of caveolin-1 and GFAP in rat spinal cord: a study of immunoblot and immunohistochemistry" pot
... desaercni yltnacifingis saw ytivitcaeronummi PAFG giF ni nwohs si star detaidarri dna lamron fo sdroc lanips eht ni noisserpxe PAFG fo sisylana tolb nretseW sisylana tolb nretseW yb dessessa sdroc ... esaercni dlof( desaercni yltnacifingis 1-niloevac fo noisserpxe eht taht dewohs 1-niloevac fo sisylana tolb nretseW sisylana tolb nretseW yb dessessa sdroc lanips detaidarri ni ... seiduts lacimehcotsihonummi dna gniniats nisoe -nilyxotameh enituor rof mµ fo ssenkciht a ot tuc erew dna ,sdohtem gniddebme niffarap dradnats gnisu dessecorp erew snemicepS 4.7 Hp ta )SBP( enilas...
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Báo cáo sinh học: "Changes in the expression of genetic characteristics across cohorts in skeletal deformations of farmed salmonids" potx
... stressor inducing the deformations Under these unexpected conditions, families showed different but consistent sensitivities to the stressor, leading to moderate heritability In the Finnish data, ... different stressors, it is possible that negative genetic correlations appear To test these hypotheses, a set of incidences and liability scale heritabilities were obtained from the Finnish rainbow trout ... deformations in these generations were determined partly by the same set of genes, or a set of closely linked genes The second major finding of this study is that genetic correlations between generations...
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The role of serum amyloid A1(SAA1) in coronary artery disease
... elucidate the surface receptors of SAA1 and the study the genetic expression induce by SAA1 in the macrophages 1.3 Thesis Organisation The thesis is organized into other chapters The thesis begins with ... alter susceptibility to the disease The phenotypic expression of the disease usually involves the interaction of several disease- causing genotypes, each conferring additional risk to disease susceptibility ... dysfunctional immune regulation on a systemic level As there are similarities in the disease 23 pathogenesis of these three diseases, it is possible that A-SAA might play a role in these diseases...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples ... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... and shown to increase Ab levels by six- to eightfold [4] These discoveries created intense interest in APP processing and paved the way for the development of more sophisticated ELISAs to selectively...
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Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
... procedures Assessments such as the WAIS bring a degree of objectivity to assessment of cognitive function; nevertheless, their use in determining the pres- Page of (page number not for citation purposes) ... symptoms as distinct and different diseases, and others have given its name to diseases differing essentially from it" [1] For instance, dementia with Lewy bodies and Parkinson 's disease are ... stages of parkinsonism, absence of standard definition of PD itself) may be another cause for discrepancies [36] James Parkinson had noted that the problem was one of classification: "The disease, ...
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Báo cáo khoa học: " 3-D reconstruction of anterior mantle-field techniques in Hodgkin''''s disease survivors: doses to cardiac structures" pptx
... Despite these efforts to reduce radiation-induced late toxicity, of which heart disease is one aspect, oncologists and cardiologist are still seeing survivors of Hodgkin 's disease treated in ... As part of an ongoing interdisciplinary study between cardiologists, radiologists and radiation oncologists, Hodgkin 's disease survivors will be invited for extensive cardiologic tests including ... mediastinal doses (mean 36.7 Gy) than patients in the MF+ROT (41.7 Gy) and MF+DORS (42.7 Gy) groups, indicating that the use of these boost techniques permitted dose increases in the mediastinum...
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Báo cáo khoa hoc:" Wnt expression is not correlated with β-catenin dysregulation in Dupuytren''''s Disease" doc
... finding being down-regulated Wnt 11 mRNA expression in disease tissue As Wnt11 signalling is independent of β-catenin and no other Wnt family members display consistent alteration in expression, ... Wnt 11 D2 Pooled W D D2 E M H2 L R T W Control Control Control Disease Disease Disease Disease Disease Disease Disease Disease Disease 5/37 4/17 1/3 0/28 1/4 0/16 0/9 0/16 0/2 2/9 5/22 11/19 9/37 ... mediator of its pathophysiology [7-9] As Wnt factors are the most upstream regulating factors of β-catenin levels, we have undertaken a comprehensive analysis of Wnt expression in this disease Of the...
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Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways ppt
... cells, whereas enrichment for the genes involved in cholesterol biosynthesis processes remained high in these cells These results demonstrate that GCN2 may be involved in the regulation of particular ... results reinforce these data, as they show that amino acid starvation affects the expression of genes involved in various biological processes related to lipids and ⁄ or energetic processes In ... (ATF4) is translationally up-regulated as a result of the presence of upstream ORFs in the 5¢-UTR of its mRNA [19,20] ATF4 then binds the amino acid response element and induces the expression of...
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báo cáo khoa học: " Field transcriptome revealed critical developmental and physiological transitions involved in the expression of growth potential in japonica rice" potx
... Organ/tissue-specific gene expression Results and Discussion Generation of gene expression profiles covering various tissues and organs We performed spatiotemporal gene expression profiling using ... spatiotemporal gene expression analysis of 48 tissues and organs at various stages of growth and by continuous gene expression profiling of leaves at weekly intervals from transplanting until harvesting Our ... change of gene expression across separate organs and tissues suggesting the possible involvement of a long distance signaling mechanism in developmental and diurnal gene expression Consistent...
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Báo cáo y học: "Could the expression of CD86 and FcγRIIB on B cells be functionally related and involved in driving rheumatoid arthritis" pps
... activation, especially in the context of in ammatory disease, requires further exploration The results presented by Catalán and colleagues go some way to support the hypothesis that RA is associated ... acts as a late checkpoint at the level of class-switched B cells or antibody-producing plasmablasts/plasma cells, and considering that autoreactive B cells are generated during the process of ... FcγRIIB is not recovered to similar levels to those detected in healthy individuals Defects in other inhibitory receptors have also been linked with RA pathogenesis, including reduced expression of...
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Effects of high glucose concentrations on the expression of genes involved in proliferation and cell fate specification of mouse embryonic neural stem cells
... diabetes induces oxidative stress in NSCs during neurulation are not clear The present study was aimed to investigate whether high glucose induces oxidative stress in NSCs, and the mechanism by ... promotes Neurog1 expression, suggesting that SHH is 18 Chapter 1: Introduction involved in the specification of trigeminal sensory neurons through the induction of Neurog1 expression as Neurog1 has ... macrovascular disease is also markedly increased The major manifestations of macrovascular diseases are atherosclerosis of coronary arteries, cerebral arteries, and large arteries of the lower...
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Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... mechanisms, such as the active degradation of HO-1 protein, might ensure constant or reduced expression levels of HO-1 protein in these cell lines under hypoxia In contrast, the expression levels of ... sequence was also confirmed by RT-PCR analysis of YN-1 RNA The 5¢-flanking sequence lacks a consensus TATA box but contains several sequence motifs for binding of transcription factors, such as Sp1 Incidentally, ... hypoxia reduces the expression levels of HO-2 mRNA and protein in five out of six cell lines, with the exception of KG1 myeloid cells A Hypoxia decreases the expression levels of HO-2 protein in YN-1...
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Tài liệu Báo cáo khoa học: Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins doc
... circles (D) The region consisting of creatine kinase (spot 6; lower lanes) and b-enolase (spot 7, upper lanes) of the same samples as in (C) is shown Signal intensities in PV– ⁄ – TA are as in WT ... and determination of phospholipids by phosphorus analysis of spots Lipids 5, 494–496 SAS Institute Inc (1989) SAS ⁄ STAT User s Guide, version 6, 4th edn SAS Institute, Cary, NC FEBS Journal ... levels, as seen in SOL These findings further support the presence of distinct pathways regulating fiber specific isoforms and metabolic enzymes, on the one hand, and mitochondrial biogenesis, on the...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... for subunit VIIa, which is expressed as isolog H and L The L isolog is ubiquitously expressed in all the tissues whereas the H isolog is detected in the heart and skeletal muscle tissues [3] The ... The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents Role for Nrf1 in gamma-gcs (1) and gss expression in mouse fibroblasts ... conditions These results suggest that changes in mitochondrial gene expression precede changes in the expression of nuclear genome coded CytOX subunits during hypoxia We also tested the level of mRNA...
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Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf
... examine whether the increased expression of Ppp2r5c transcripts was specifically modulated by Nrl, we used Nrl small interfering RNA (siRNA) transfectants in which the expression of Nrl was approximately ... for Nrl -mediated Ppp2r5c expression Results Conserved sequences of the Ppp2r5c promoter contain Nrl-binding sites In the search for conserved putative regulatory elements, the sequence of the human ... of rods but enhanced S- cones [21] In humans, missense mutations of NRL are associated with autosomal dominant retinitis pigmentosa [22], and this disease may be a result of altered transcriptional...
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Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
... Analyses of novel Thermus competence proteins J Rumszauer et al systems of thermophiles and extreme thermophiles is very scarce To get insights into the transformation systems of thermophilic ... proteins are structural subunits of the T thermophilus pilus structures To address this question, we purified the pili structures by separating shear fractions of T thermophilus HB27 in a discontinuous ... chose T thermophilus HB27, which exhibits the highest transformation frequencies among the Thermus strains, as a model strain [4] On the basis of the complete genome sequence of T thermophilus...
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Báo cáo khoa học: Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) ppt
... GalNAc-transferases Arrows indicate cysteine residues and the numbers indicate residues mutated in this study The amino acid residue numbering is based on the GalNAc-T1 sequence Highly conserved cysteine ... procedures RESULTS Involvement of the free cysteine residues of GalNAc-T1 in catalysis To investigate the functional role of the cysteine residues (Fig 1), we first modified GalNAc-T1 with a cysteinespecific ... Cys212, are involved in substrate binding, possibly as hydrogen bond partners with UDP DISCUSSION The primary aim of this study is to evaluate the functional role (s) of the conserved cysteine...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... gene in HD mouse brain This supports the hypothesis that the rate of transcription of CB1 in the striatum of symptomatic R6/2 mice is similar to the rate of transcription in regions of the brain ... the expression of CB1 in the striatum vs the cortex or expression of CB1 in transgenic HD mice To test the hypothesis that expression of mutant huntingtin decreased CB1 transcription, we measured ... huntingtin leads to cell-specific dysregulation of the levels of CB1 mRNA The overall goal of this research was to determine how expression of mutant huntingtin selectively alters the steady-state...
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Báo cáo khoa học: Factors involved in the assembly of a functional molybdopyranopterin center in recombinant Comamonas acidovorans xanthine dehydrogenase pot
... molybdopyranopterin site (the catalytic site for most of the enzymes in this class) adds further difficulty in the successful expression of molybdoenzymes in the xanthine oxidoreductase family The most important ... oxidase in E coli [36] does not require the coexpression of an MPT insertase, as there was no mention of a dependence of the level of culture aeration in the expression of recombinants These results, ... in E coli suggests the potential for success in expressing a recombinant XDH in this organism Expression of XDH requires the incorporation of the MPT center, placement of the terminal sulfur ligand...
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