optimum glass former in the low solute content region of the al rich al ni hf alloy
Trinucleotide (CAG) repeat polymorphism of the androgen receptor gene in human disease
... stretches With the exception of the X-linked SBMA, they all share the autosomal dominant mode of inheritance and anticipation on paternal transmission The position of the poly-Gln in the coding region ... of the exon and contains the major part of the AR nuclear targeting signal formed by a cluster of basic amino acids (arginine, lysine, leucine, and lysine) at positions 629-633 The function of ... between the different proteins For instance for AR and huntingtin, the poly-glutamine expansion are located within the amino terminal region, while for the atrophin is near in the Cterminus (Choong...
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GT-repeat polymorphism in the heme oxygenase1 gene promoter and the risk of carotid atherosclerosis related to arsenic exposure ppt
... areas of arsenic exposure in Taiwan: the Lanyang Basin in the northeastern coastal region and the Blackfoot disease (BFD)-endemic area in the southwestern coastal region [22] Epidemiological biomarker ... arsenic exposure In the multivariate models including conventional risk factors, the effect of arsenic exposure seemingly differed between carriers of the class S allele and non-carriers of the allele ... Catholic University, Taipei, Taiwan 4Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 5Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University,...
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Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients potx
... 377) Each size of the (GT)n repeat was calculated using the GeneScan Analysis software (PE Applied Biosystems) Statistical analysis The distribution of the numbers of (GT) n repeats of two DNA strands ... presence of lipid conditions, that is, the levels of HDL-C, it may explain the controversial findings in the literatures Similar as the previous CAD studies, we did not find the significant difference ... composition of cholesterol levels in patients with normal total cholesterol levels Many studies reported that HO-1 gene involved in the mechanism against the development of atherosclerosis Animal studies...
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Báo cáo y học: "Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese" potx
... combined in males (P = 0.002) (Table 2) The significance remained after applying the Bonferroni correction No significance was found in other alleles for comparisons of one allele vs all remaining ... Chinese Han living in and around Nanjing No subjects dropped out during the process of the study The study was approved by the ethical committee of the participating institutions, and informed consent ... one allele vs all the remaining alleles combined We stratified subjects by gender and compared the allelic frequency In female subjects, significant differences were observed in a comparison of...
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Báo cáo y học: "Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis" ppsx
... results in a nonconservative amino acid substitution in which arginine, with a highly basic side chain, replaces methionine, which has a nonpolar side chain (methionine → arginine, M196R) The location ... polymorphism in exon of the TNF-RII gene occurs within the fourth cysteine -rich domain of the extracellular domain, close to a point where the proteolytic cleavage site for TACE is thought to lie [37] The ... between increasing levels of both sTNFRs and age, which was independent of disease duration An explanation for these conflicting data is not yet evident The clinical relevance of our findings is...
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Báo cáo y học: "A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation" potx
... associations with clinical variables were difficult to calculate owing to the low prevalence of the rarer allele of the C+1354T SNP in SSc patients; however, from an exploratory point of view, the His452Tyr ... confirm previous findings indicating that 5-HT is more relevant in the maintenance of the vascular phenomena that underlie the pathogenesis of SSc, rather than in determining their onset [38] ... associated with any of the following: the disease subset, the anticorpal status, age at the onset of the disease, past history of digital ulcers, the forced viral capacity, the diffusing capacity for...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... levels in the medial striatum of any of the wild-type and HD mice examined The optical density of the hybridization signal in the lateral striatum, corrected by subtracting the signal in the medial ... levels of mutant huntingtin protein are lower in the R6/1 mice compared to R6/2 [10] and that neuronal intranuclear inclusions (NIIs) containing the human transgene-encoded amino terminus of human ... preferentially lost in the striatum of HD mice Further, the final equilibrium levels of each CB1 transcript in the striatum of HD mice was the same as the basal levels of CB1 mRNA found in the cortex in...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf
... absence of R1881 (C) Western analysis of indicated GalAD-AR.NTD proteins in the yeast protein interaction system (left panel) and of indicated AR.NTD proteins in the mammalian protein interaction ... Alanine scanning of AR17–32: amino acids flanking F23, L26 and F27 modulate AR N/C interaction (A) GalAD-ARpeptide fusion proteins in the yeast protein interaction system (B) Interaction of GalAD-ARpeptides ... AR3)36 subdomain AR3)13 in N/C interaction and the role of individual amino acid residues in and flanking the 23 FQNLF27motif in AR16)36 in N/C interaction Yeast protein interaction assays indicated...
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Báo cáo y học: "No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren''''s syndrome" pptx
... -70°C in RNAlater (Qiagen, Valencia, CA) Total RNA was extracted from PBMCs using RNeasy Mini Kit (Qiagen) The cDNA synthesis was performed using Enhanced Avian HS RT-PCR (Sigma-Aldrich, Saint ... dose of ≤10 mg of prednisone; n = 14) or hydroxychloroquine (n = 13) Of the 162 patients, 95 were included in a previous study in which BAFF level was reported [8] The methods of assessment of ... protein, which inhibits secretion of BAFF [18], would also increase BAFF protein level without affecting BAFF mRNA level The absence of concordance between BAFF protein and mRNA regarding the...
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Báo cáo y học: "Replication of association of the D-repeat polymorphism in asporin with osteoarthristis" docx
... definition, inclusion criteria, genotyping and analytical methods, and to unite the ethnically diverse resources available for study Such efforts would increase the accuracy and power of the ... chance alone However, this analysis includes the result used as reference, the Japanese study, in the subject of the comparison The correct probability is 1/8 = 0.125 Regarding the comment on the ... Gomez-Reino and Antonio Gonzalez The letter from Ikegawa and colleagues highlights some difficulties in defining what constitutes replication of previous genetic association in the context of studies...
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Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc
... the result of a single SNP in Ncf1, resulting in the shift from threonine to the disease-promoting methionine at position 153 in the p47phox protein [21] The consequences of the amino acid shift ... Nonetheless, in order to obtain an indication of the validity of the P values obtained in these analyses, we used the Bonferroni correction method to estimate an α level correcting for the number of tests ... causing the haplotype association Homozygosity could explain the genetic risk associated with rs729749 The rs726749 SNP is noncoding and located in the beginning of intron in NCF4 Analysis of the...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
... epithelium of the terminal ileum with cytoplasmic staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the colon C Staining ... does in macrophages The most intense cytoplasmic staining occurred in the terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin -rich ... staining most vividly (Figure 1A,1B,1C) Examination of the intracellular staining pattern revealed a characteristic staining pattern with the terminal web and the lateral junctions of intestinal...
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Báo cáo y học: "A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis" ppt
... lack of power Finally, replication of our findings in an independent dataset is needed to confirm the implication of the MTHFR A1298C gene polymorphism in the increased risk of atherosclerosis of ... RA in the Spanish population [13] The association of the MTHFR A1298C gene polymorphism with CV events in Spanish individuals with RA therefore seems to be independent of the potential role of ... whether these two MTHFR gene polymorphisms might be associated with an increased risk of and subclinical atherosclerosis manifested by the presence of endothelial dysfunction in RA Materials...
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Báo cáo y học: " A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis" doc
... Materials and methods Study populations and clinical evaluation Twenty patients with established RA and 26 healthy individuals were enrolled in the study The average age of the healthy individuals ... serum/phosphate-buffered saline (NCS/PBS) buffer and fixed overnight in 4% paraformaldehyde The cells were then permeabilized with 0.5% saponin in 2% NCS/PBS Intracellular cytokine staining was performed using fluorescein ... Understanding the mechanisms of Th17 regulation in human disease is essential for the development of novel, targeted therapies and to guide therapeutic decision-making Several findings suggest that the...
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Báo cáo khoa học: "Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study" docx
... participated in the design of the study and drafting of the manuscript RM participated in the design of the study, genotype analysis, statistical analysis and drafting of the manuscript TR participated in ... septic insult may help to explain some of the residual variability observed in a previous study attempting to link exogenous insulin administration to ADMA levels [13] Thus, interindividual variability ... non-functional iNOS gene are susceptible to infection [20] Furthermore, in clinical Page of (page number not for citation purposes) Critical Care Vol 10 No O'Dwyer et al trials of NOS inhibition in patients...
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Báo cáo sinh học: " Expression pattern and polymorphism of three microsatellite markers in the porcine CA3 gene" pptx
... from the beginning of intron Microsatellite SJ158 which includes a tandem repeat of (GT)n is located approximately at 240 bp from the beginning of intron and the novel microsatellite, which included ... the observation of the trait; µ is the least squares mean; Gi is the effect of the ith genotype; Sj is the effect of the jth sex (j = for male or for female); Fk is the effect of year; bijk is the ... In this study, we studied the allele frequencies of three microsatellite loci in the CA3 gene in seven pig breeds We report the allele frequencies and the results of association analyses of the...
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The androgen receptor centric transcriptional network in prostate cancer
... and other Motifs in ARBS Like other DNA binding transcription factors, the AR DNA binding domain is mainly responsible for determining its DNA binding specificity and affinity To determine the ... Determining the Transcriptional Mechanisms and the Specificity Underlying the AR-ERGHDACs-EZH2 transcriptional Cross-Talk 127 5.2 Unraveling the Dimensional Transcriptional Interactome of ... transcriptional activation units (AF-1 and AF-5), a DNA binding domain (DBD) where four-cysteine zinc-binding domains are located, a ligand binding domain (LBD) harboring another transcriptional activation...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates actin-binding in several proteins, such as villin and dematin [59] ... contains an N-terminal domain harboring activation function 1, a central DNA-binding domain (DBD) and a C-terminal ligandbinding domain (LBD) containing activation function [67–70] Upon binding ... naturally occurring C-terminal 100 kDa fragment of filamin, interacting with the motor protein dynein, may exert its inhibitory effect by interfering with interactions between the N- and C-terminal...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... bands are indicated by solid arrowheads Fig Microsequencing analysis of the MREa-binding proteins (A) The N-terminal sequence of the 82-kDa band was identical to amino-acid positions 6–16 of the Ku-80 ... transcriptional response of the MT gene to heavy metals [10,12], the presence of MREs in the promoter of the WD gene suggests that MREs and their cognate binding proteins function in the regulation of ... CGATCGGGGCGGGGCGAGC-3¢ (underlined bases denote the functional core of the MREs and the Sp1 binding element, and the mutated bases are indicated by italic type) Western blot analysis The MREa-binding proteins purified...
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Báo cáo khoa học: Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties pdf
... N-terminal and central domains and the dipyrromethane cofactor is covalently linked to Cys261 The interaction of the cofactor with the enzyme side chains is well understood The position of the ... However, the most common clinical presentation is abdominal pain caused by neurovisceral crises [4] Individuals differ from each other with respect to their biochemical and clinical manifestations, ... d-aminolevulinic acid synthase The upregulated activity of this enzyme increases the production of the potentially toxic porphyrin precursors, d-aminolevulinic acid and porphobilinogen (PBG) [3] Clinical...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25