bệnh hở van hai lá và hẹp hở van hai lá hohl hohhl
báo cáo khoa học: "Nanoparticles – known and unknown health risks" pot
... (penetration) The skin of most mammalian species is, on most parts of the body, covered with hair At the sites, where hair follicles grow, the barrier capacity of the skin differs slightly from the "normal" ... of inhaled nanoparticles the translocation to the systemic circulation is an important issue Conhaim and co-workers [49] found that the lung epithelial barrier was best fitted by a three-poresized ... play a role Particles (0.1–1.0 micron) are associated with the disease and indicated as potent adjuvants in model antigen-mediated immune responses In a double-blind randomised study, it has been...
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Báo cáo y học: "Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice" ppt
... littermates obtained by breeding heterozygous mutants Genotypes were determined by polymerase chain reaction (PCR) analysis of tail biopsies to detect either the presence of the inactivating ... determined by dividing the number of vessels in that category by the total number counted in the relevant group of animals For fully muscular vessels, video images were obtained and arterial diameters ... 15 minutes at 70°C The cDNA was diluted 1:40 for use in the real-time quantitative polymerase chain reaction Amplification was performed in duplicate using the ABI Prism 7000 system (Applied...
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Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta
... inflammatory 92 response to a broad spectrum of stimuli J Exp Med 1996; 184: 2429-32 [37] Holt PG, Haining S, Nelson DJ, Sedgwick JD Origin and steady-state turnover of class II MHC-bearing dendritic...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... messenger RNA Crit Care Med 2002, 30(8):1693-1700 70 Vaneker M, Joosten LA, Heunks LM, Snijdelaar DG, Halbertsma FJ, van Egmond J, Netea MG, van der Hoeven JG, Scheffer GJ: Low-tidal-volume mechanical ... macrophages Respir Res 2010, 11:124 36 Maris NA, Dessing MC, de Vos AF, Bresser P, van der Zee JS, Jansen HM, Spek CA, van der Poll T: Toll-like receptor mRNA levels in alveolar macrophages after inhalation ... Care Med 2003, 168(8):918-951 112 Greene CM, Carroll TP, Smith SG, Taggart CC, Devaney J, Griffin S, O’Neill SJ, McElvaney NG: TLR-induced inflammation in cystic fibrosis and noncystic fibrosis airway...
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Báo cáo y học: "A neonate with left pulmonary artery thrombosis and left lung hypoplasia: a case report" pps
... Evidence-Based Clinical Practice Guidelines Chest 2008, 133:887S-968S 12 Goldstein JD, Rabinovitch M, Van Praagh R, Reid L: Unusual vascular anomalies causing persistent pulmonary hypertension in a ... of Medical Case Reports 2010 4:284 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color...
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Báo cáo y học: " A neonate with left pulmonary artery thrombosis and left lung hypoplasia: a case report" pot
... Evidence-Based Clinical Practice Guidelines Chest 2008, 133:887S-968S 12 Goldstein JD, Rabinovitch M, Van Praagh R, Reid L: Unusual vascular anomalies causing persistent pulmonary hypertension in a ... of Medical Case Reports 2010 4:284 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color...
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Báo cáo y học: " Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin" potx
... at 14 dpi by histopathology and collagen assays We also used reverse transcription polymerase chain reaction to measure the mRNA expression level of transforming growth factor β1 (TGF-β1) in...
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Báo cáo y học: " Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model" pot
... stained with 2% aqueous uranyal acetate and then lead citrate Reverse transcriptase-polymerase chain reaction Total RNA was extracted from lungs of three rats from each group tissues of rat by ... studies, we also found recruitment of ED-1 positive PIMs in BDL rats ED-1 antibody binds to a single chain 110 kD glycoprotein expressed in lysosomes of monocytes/macrophages Due to spatial resolution ... Second, we found a significant reduction in the concentrations of these important and highly relevant cytokines in PIM-depleted LPS-treated BDL rats compared to LPStreated BDL rats, which could...
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Báo cáo y học: "An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice" ppsx
... histological lung sections of the same animals The tissue area was also measured using MIP 45 Advanced System image analysis software (Microm España, Barcelona, Spain) to express the number of ... 0.13* 0.365 ± 0.06 a mRNA expression was analyzed by conventional reverse transcriptase-polymerase chain reaction and the expression ratios compared with GAPDH were determined by densitometry No differences ... guarantee an effect [30] Our goal was to ensure efficient downregulation of COX-2 mRNA during the relevant phases of sensitization and challenge In contrast to systemic inhibition of the enzyme [23-27],...
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Báo cáo y học: "Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study" pdf
... Japan) Expression of cytokine mRNA Quantitative real-time reverse transcription (RT) polymerase chain reaction (PCR) was performed to measure the relative levels of expression of lung inflammatory ... cytokines and c-fos m-RNA expression in an isolated rat lung model J Clin Invest 1997, 99(5):944-952 Haitsma JJ, Uhlig S, Goggel R, Verbrugge SJ, Lachmann U, Lachmann B: Ventilator-induced lung injury ... The Acute Respiratory Distress Syndrome Network N Engl J Med 2000, 342(18):1301-1308 Schultz MJ, Haitsma JJ, Slutsky AS, Gajic O: What tidal volumes should be used in patients without acute lung...
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Báo cáo y học: "A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice" pps
... COPD [2123] Orally active PDE4 inhibitors such as cilomilast and roflumilast have reached an advanced clinical stage [2426] However one major hurdle in their development has been overcoming the ... 3–6 per group for pro-MMP-9) Delivery of AON directly to the lung via inhalation presents key advantages over systemic delivery of small molecule PDE4 inhibitors Inhalation of AONs achieves appreciable ... airways in COPD Thorax 2006, 61:448-454 Cowburn AS, Condliffe AM, Farahi N, Summers C, Chilvers ER: Advances in neutrophil biology: clinical implications Chest 2008, 134:606-612 Pesci A, Balbi B, Majori...
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Báo cáo y học: " Dietary intake, lung function and airway inflammation in Mexico City school children exposed to air pollutants" doc
... are the independent variables with fixed effects and εi vector of residual components A further advantage of the models used is that they not discard subjects with incomplete data and take into ... detrimental nutrients The index was modified slightly to fit a child population [40] One of the advantages of this index is that it takes into account synergic effects or interactions between foods ... school children who took part in the study, the personnel who carried out the field work and Garth Evans for his editorial assistance The study was supported by Mexican Sciences and Technology Council...
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Báo cáo y học: " CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo" ppsx
... lung injury in mouse Cell Tissue Res 2005, 321:75-88 Knapp S, Wieland CW, van' t veer C , Takeuchi O, Akira S, Florquin S, van der Poll T: Toll-like receptor plays a role in the early inflammatory ... and bind to the same receptor system (TLR9) [24-26] The identification of TLRs has been a major advance in the understanding of the pathogenesis of septic shock [27] To date, 13 TLRs (TLR1-13) have ... TLR9-D mice hrs after CpG-ODN challenge, WT mice developed shock-like symptoms including ruffled hair, eye exudates, and lethargy, while TLR9-D mice were not affected Pulmonary gene and protein...
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Báo cáo y học: " Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice" ppt
... achieving carboxyhaemoglobin levels similar to smokers and particulate densities known to be relevant, our smoke exposure system also achieves exposure to nicotine levels high enough to suppress...
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Báo cáo y học: " Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS" pot
... (CDC) case definition of SARS [12] SARS was confirmed by either positive real-time polymerase chain reaction (PCR) assays or elevated serum anti-coronavirus antibody by ELISA or both Nasopharyngeal-aspirate ... 12 patients), exertional dyspnea (6 of 12 patients), joint pains (4 of 12 patients) and partial hair loss (11 of 12 patients) At 90 days, all the 12 SARS patients were well without any of the ... syndrome; IVIG, intravenous immunoglobulin; CoV, coronavirus; OD, optical density; PCR, polymerase chain reaction Data are shown as mean ± SEM *The cut value of positive SARS infection is 0.12 OD...
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Báo cáo y học: " Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness" pptx
... inflammation Cytokine & Growth Factor Reviews 2003, 14:489-502 Vogelzang PFJ, van der Gulden WJ, Folgering H, Heederk D, Tielen MJM, van Schayck CP: Longitudinal changes in bronchial responsiveness associated ... inflammation in healthy subjects Am J Respir Crit Care Med 1994, 150:973-977 Dosman JA, Senthilselvan A, Kirychuk SP, Lemay S, Barber EM, Willson P, Cormier Y, Hurst TS: Positive human health effects ... cytokine release in the upper and lower airways Eur Respir J 1997, 10:381-387 Kirychuk SP, Senthilselvan A, Dosman JA, Zhou C, Barber EM, Rhodes CS, Hurst TS: Predictors of longitudinal changes in...
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Báo cáo y học: "Role of CD14 in lung inflammation and infection" pptx
... factor receptor-deficient mice J Infect Dis 2004, 189:711–716 Wieland CW, Van der Windt GJ, Wiersinga WJ, Florquin S, Van der Poll T: CD14 contributes to pulmonary inflammation and mortality during ... innate immunity through Toll-like receptor J Virol 2009, 83:1492–1500 Dessing MC, Van der Sluijs KF, Florquin S, Van der Poll T: CD14 plays a limited role during influenza A virus infection in ... roots: the story of endotoxin Nat Rev Immunol 2003, 3:169–176 Knapp S, Florquin S, Golenbock DT, Van der Poll T: Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung...
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Co operation between humoral and cellular immunity in pulmonary lung inflammation
... sensitised with intraperitoneal OVA with aluminium hydroxide adjuvant (which favours a Th2 response), but not if sensitisation was without adjuvant [16] Although mast cells can cause AHR, it can also ... investigated In order to evoke these responses, OVA with an aluminium-based adjuvant was administered intraperitoneally (i.p.) An adjuvant is an agent that enhances the immunogenicity of an antigen and many ... comparison Adjuvants from a panel of sources were tested (Figure 4) There were no observed significant differences in the OVA-IgG1 and total IgE responses obtained between the panel of adjuvants used...
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Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
... Cochrane Database Syst Rev 2005, 4:CD003566 15 van Gestel YR, Hoeks SE, Sin DD, Welten GM, Schouten O, Witteveen HJ, Simsek C, Stam H, Mertens FW, Bax JJ, van Domburg RT, Poldermans D: Impact of cardioselective ... obstructive pulmonary disease and atherosclerosis Am J Respir Crit Care Med 2008, 178(7):695-700 16 van Zyl AI, Jennings AA, Bateman ED, Opie LH: Comparison of respiratory effects of two cardioselective ... population Respiratory Research 2011 12:50 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color...
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Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... polymorphisms found through literature searches and checked their references for additional relevant studies Of the relevant 18 studies, studies appeared to be on populations already reported [14, 18, 19], ... same authors Case-control studies were eligible if they had determined the distribution of the relevant genotypes in lung cancer cases and in concurrent controls using a molecular method for genotyping ... with XP, TTD involves mutations Materials and methods 2-1 Identification and eligibility of relevant studies 2-2 Data extraction and assessment of study quality For each study, characteristics...
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