bảo hiểm thất nghiệp đã thu hút được sự tham gia đông đảo của người lao động
Báo cáo y học: "JNK suppression is essential for 17b-Estradiol inhibits prostaglandin E2-Induced uPA and MMP9 expressions and cell migration in human LoVo colon cancer cells" ppsx
... Upregulation of MMPs is reported to contribute to ECM remodeling, tumor cell invasion and metastasis, thus leading to the development of malignant tumor [5] Both mRNA levels MMP-2 and MMP-9 have been ... upregulation of MMP-2 and MMP-9 accelerates cell migration and invasion in colorectal cancer [9], thus resulting in the development of malignant tumor, poor prognosis, and shortening disease-free ... cancer cells Administration of prostaglandin E2 (PGE2) rapidly activates kinase such as JNK1/2, thus leading to the expression of downstream targets including uPA and MMP-9, which further promotes...
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Báo cáo khoa học: Expression of heme oxygenase-1 is repressed by interferon-c and induced by hypoxia in human retinal pigment epithelial cells pot
... Bach1 mRNA, but decreased the mRNA levels of Nrf2, a transcriptional inducer of the HO-1 gene [49] Thus, the expression levels of HO-1 and Bach1 mRNAs were concomitantly increased in D407 cells under ... with the maximum induction by h, each of which activates the transcription of the human HO-1 gene Thus, the hypoxiamediated induction of HO-1 expression may be a consequence of the production of ... Importantly, the hypoxia-mediated induction of HO-1 mRNA was prevented by the treatment with cycloheximide Thus, RNA synthesis and new protein synthesis are 3080 R Udono-Fujimori et al (Eur J Biochem 271)...
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Báo cáo khoa học: Stage-specific activation of MIG-17⁄ADAMTS controls cell migration in Caenorhabditis elegans docx
... suggesting that endogenous activated MIG-17 is expressed below the level of detection of the antibody Thus, we stained animals expressing the MIG-17–GFP fusion protein, which can rescue mig-17 mutants ... in mig-17 mutants meanders from the first turn (mid-L3) to the cessation of migration (late L4) Thus, it is reasonable that the MIG-17 localized to the gonadal basement membrane is activated during...
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Báo cáo khoa học: Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing docx
... edge, < 10% of the CasKo cells at the wound edge showed localization of Cdc42 on the leading edge Thus, Cas is required for trafficking of Cdc42 to the leading edge of migrating cells In addition ... however, we cannot rule out the possibility that Nck2 is more abundantly expressed in CasWt cells and, thus, Nck2-knockdown resulted in a more significant disruption of polarization than Nck1-knockdown...
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Báo cáo Y học: Bax-induced cell death in yeast depends on mitochondrial lipid oxidation doc
... ROS concentrations, thus having deleterious effects on biological constituents Release of cytochrome c obviously leads to an increase of the reduced state of ubiquinone, thus favoring the reduction ... used Plasmids used throughout the study carry URA3 or TRP1 genes and uracil and tryptophan are thus used as selection markers For cells transformed by a tet-off/h-Bax construct, 10 lgÆmL)1 doxycyclin ... at 565 nm (excitation at 495 nm) Conditions were adjusted on a strain inactivated for SOD1 gene, thus producing high amounts of ROS F565nm increases for 45 min, reaches a plateau and eventually...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
... has the unique biochemical feature to be directly activated by heterotrimeric G proteins and was thus initially considered as the best candidate target of LPA [56] On the other hand, it has been ... Grb2–Sos complex to activate EGF receptor [59], which is followed by stimulation of Ras [60] In mesangial cells LPAinduced ERK 1/2 activation was shown to depend on platelet-derived growth factor (PDGF) ... activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cells Biochem J 345, 217–224 ...
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cell migration in inflammation and immunity
... an immediate– early platelet-derived growth factor (PDGF)-inducible gene in fibroblasts (10,11) Thus, in the mid-1980s, a gene (JE) was in search of function and a monocytespecific attractant ... Natl Acad Sci USA 91, 7291–7295 32 Taraboletti, G., Belotti, D., Dejana, E., Mantovani, A., and Giavazzi, R (1993) Endothelial cell migration and invasiveness are induced by a soluble factor produced ... capillary tubes are cocoated with purified ligands for selectins and integrins and with chemokines, thus reconstituting the minimal requirement to support tethering, rolling, and arrest under flow...
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Báo cáo y học: " Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands" docx
... a potential role for TNFSF4 in autoimmune exocrinopathy Arthritis Res Ther 2008, 10:R137 35 McArthur C, Wang Y, Veno P, Zhang J, Fiorella R: Intracellular trafficking and surface expression of...
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Báo cáo y học: "Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis" docx
... was synthesised using dNTP and Moloney Murine Leukaemia Virus reverse transcriptase (Promega, Southampton, UK) gene (acidic ribosomal protein) Values were normalised to a reference sample of pooled ... by utilising total RA synovial membrane cells, which include macrophages as well as fibroblasts, thus possibly explaining the differences between these published data and our own Page of 11 (page ... AC, Denko NC, Hudson KM, Schindler C, Swiersz L, Koch C, Evans S, Ibrahim H, Le QT, Terris DJ, Giaccia AJ: Candidate genes for the hypoxic tumor phenotype Cancer Res 2000, 60:883-887 Demasi M,...
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Báo cáo y học: "Directed cell migration in the presence of obstacles" doc
... cellular organisms, which may be simply involved in following chemoattractant left by their prey and thus have no apparent foreknowledge of any obstacles in their path These are the cases we shall ... this follows theoretically from a consideration of receptor kinetics (see [16] for example) It thus follows that the cell's movement can be modeled via an over-damped equation of the form: x ... diffusion coefficient and that the last two expressions are correct up to some multiplicative constant Thus the steady state assumption is valid if the inequality αgR/Dc
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Genetic analysis of the role of ARP2 3 complex in border cell migration in drosophila melanogaster
... express my gratitude to Dr Pernille Rørth for her supervision and guidance on the project Her enthusiasm on science has been affecting the group every day Help from many people contribute to the ... tracking shows that Arp2/3-impaired border cells are still motile, but show less directional movement Thus Arp2/3 may be acting upstream or downstream of guidance cues to steer border cell migration ... et al 1978) allowing the rapid growth at the barbed end drives protrusion of cell membrane and thus cell motility (Pollard et al 1982) Actin remodeling has an essential role in various processes,...
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Cancer cell migration in 3d collagen gel matrix system
... invested tremendous time and energy to guide us His foresight of frontier science, his wisdom, enthusiasm and intelligence guided my research like a lighthouse Whenever I had difficulties in anything ... Metastasis causes the dissemination of cancer cells and accounts for 90% of cancer-induced deaths, thus requiring better therapeutic treatments The thesis examines a functional assay to study cancer ... population aging With an extended lifespan, people are subjected to more carcinogenic exposures and thus, are prone to developing cancer [2] If the trend continues as projected, combating cancer will...
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CHARACTERISATION OF DRUG INDUCED CELL DEATH IN MYCOBACTERIUM SMEGMATIS
... unique cell wall of Mycobacteria poses as an ideal target for drugs Thus, two of the four first line drugs (isoniazid and ethambutol) used in tuberculosis treatment are Mycobacterium cell wall ... inhibits INH A activity thereby interrupting mycolic acid synthesis (Lei, Wei, & Tu, 2000) Ethambutol Ethambutol also inhibits mycobacterial cell wall synthesis Mycolic acids attach to the 5’-hydroxyl ... arabinose residues to form glycosidic linkages with D-galactan Ethambutol is a specific inhibitor of the arabinosyl transferases, thus preventing the formation of cell wall (Takayama & Kilburn,...
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Tài liệu Báo cáo khoa học: Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B doc
... NADPH oxidase for ROS production which then causes the phosphorylation of IKK-b and IjB-a, and thus activation of NF-jB Consensus DNA-binding motifs for NF-jB proteins exist in the promoters ... inflammatory mediators by blocking NF-jB activation in macrophages Mol Pharmacol 69, 1783–1790 16 Laos S, Baeckstrom D & Hansson GC (2006) Inhibition of NF-kappaB activation and chemokine expression...
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Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
... in human tumor cell growth, survival, and invasion Cancer Res 64, 6160–6165 17 Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos K, Pastorek J, Wykoff CC, Gatter KC & Harris AL (2001)...
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Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells pptx
... (2001) Phosphorylation of Bcl2 and regulation of apoptosis Leukemia 15, 515– 522 Blagosklonny MV, Giannakakou P, el Deiry WS, Kingston DG, Higgs PI, Neckers L & Fojo T (1997) Raf-1 ⁄ bcl-2 phosphorylation:...
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Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
... characteristic feature of apoptotic cells, was also observed at 25 lM Zn in the presence of lM Py (Fig 1C) Thus, the features of cell death changed depending on the intracellular Zn levels Induction of apoptosis...
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Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx
... Unphosphorylated, recombinant SF2/ASF is a basic protein and is known to bind nucleic acids nonspecifically [20] Thus, a trivial explanation for the inhibition of the DNA cleavage could be that SF2/ASF preferentially ... because it had previously been reported to bind nonspecifically to nucleic acids [21] SF2/ ASF could thus preferentially bind to DNA and prevent this way DNA from cutting by htopo I We excluded this ... htopo I on DNA, either by noncovalent binding or in the form of the cleavable complex One might thus speculate that, if SF2/ASF inhibits the reaction catalysed by htopo I (see below), stabilization...
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Báo cáo khoa học: Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells doc
... temperature of 60 °C and were subjected to PCR for 35 cycles in a thermocycler (PerkinElmer, Waltham, MA, USA) All sequences are indicated in the 5¢ to 3¢ direction and are abbreviated after the...
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