cập nhật các hướng dẫn kiểm soát acid uric và bệnh gout từ các khuyến cáo quốc tế

Prevalence generally ranges from < 1% to 4%Gout is the most common form of inflammatory arthritis in adults and the second most common form of arthritis a,cUS 2011: 8.3 million gout, 43

Prevalence generally ranges from < 1% to 4%

Gout is the most common form of inflammatory arthritis in adults and the second most common form of arthritis (a,c)

US (2011): 8.3 million (gout), 43 million (hyperuricemia)

Cácviêm

hóa purin và H/C hóa

RLCH Purin gianhanh trong 2 niên

Theo AHA (American Heart Association):

(HK 28,8 % ~ )

Frances Rees, Michelle Hui & Michael Doherty Optimizing current treatment of gout Nature Reviews Rheumatology 10, 271 283 (2014) Published online 11 March 2014

- ACID URIC

Gout

(80%-90% of all gout patients)(5%-10% of all gout patients)

Acid Uric

Gout: An old disease in new perspective - A review.

Gaafar Ragab, MohsenElshahaly, ThomasBardin Journal of Advanced Research Volume 8, Issue 5 September 2017, Pages 495-511

kháng viêm không có Steroid (NSAID), Colchine

Allopurinol: 200 800 mg/ngày (TB 300 mg/ngày) Febuxostat: 40 120 mg/ngày (TB 80 mg/ngày)

American College of Rheumatology Guidelines for Management of Gout (ACR 2012/2015)

máu (HD) = 0.6mg x 2 /1 (not dialyzable)

acid uric tay là nhómmen XO (Xanthine Oxidase Inhibitor- XOI).

tiêu acid uric <6 mg/L là, <5

phòng trong 3 tháng (không tophi) 6 tháng (có tophi) sau khitiêu acid uric.

ACR 2012/2015:- ULT

Khanna D, et al Arthritis Care Res (Hoboken) 2012 Oct;64(10):1447-61

uric ngay

(> 480 mmol/L)

EULAR recommendation for Treating to Target 2017

2016 EULAR Recommendations for the Management of Gout

Richette P et al Ann Rheum Dis 2017;76:29-42

2016 EULAR Recommendations for the Management of Gout

Richette P et al Ann Rheum Dis 2017;76:29-42

The British Society for Rheumatology Guideline for the Management of Gout (BSR 2017)

Michelle Hui et al., Rheumatology 2017;56:e1-e20

Schumacher HR Jr, et al BMJ 2002;324(7352):1488 1492; Rubin BR, et al Arthritis Rheum 2004;50(2):598 606Zhang S & Zhang Y & Liu P Clin Rheumatol (2016) 35:151 158.

Michelle Hui et al., Rheumatology 2017;56:e1-e20

BSR 2017

- ACID URIC

Improving cardiovascular and renal outcomes in gout: what should we target ? The Lancet Journals Published Online: 21 April 2016

< 5 mg/dl (< 300 mmol/l)

Gout (Tophi), CKD, CV disease Gout (Ko có tophi, khác)

How Gout can Kill You

Improving adherence to gout therapy: an expert review

Fernando Perez-Ruiz, Giovambattista Desideri Dove Press Ltd May 2018 Volume 2018:14 Pages 793802

Gout 20

-Improving adherence to gout therapy: an expert review

URAT1Uric acid transporter

MCP-1monocyte chemotactic protein -1NONitric oxidevasodilatation factor

sinhnhân Gout

1 RLCH Purin và acid uric máu ngày càng gia và liên quan

urate

Acid Uric

soát acid uric máu soát acid uric máu