This is a comprehensive set of guidelines on the management of cardiovascular disease in pregnancy Roos-Hesselink JW, Ruys TP, Stein JI, et al Outcome of pregnancy in patients with structural or ischaemic heart disease: results of a registry of the European Society of Cardiology Eur Heart J 2013;34:657–665 This is the original outcomes study from the European Registry on Pregnancy and Cardiac Disease (ROPAC registry) Pregnancy outcomes in 1321 women from 28 countries were reported Maternal mortality was 1% and was most common in women with cardiomyopathies Twenty-six percent of women were hospitalized during pregnancy Maternal and fetal mortality were higher in developing countries Silversides CK, Grewal J, Mason J, et al Pregnancy outcomes in women with heart disease: the CARPREG II study J Am Coll Cardiol 2018;71(21):2419–2430 This large (1938 pregnancies) multicenter study examined cardiac complications in pregnant women with heart disease Ten predictors of cardiac complications were identified and incorporated into a risk index, the CARPREG (Cardiac Disease in Pregnancy Study) II risk score Siu SC, Colman JM, Sorensen S, et al Adverse neonatal and cardiac outcomes are more common in pregnant women with cardiac disease Circulation 2002;105:2179–2184 The Cardiac Disease in Pregnancy (CARPREG) study was the first prospective study to examine cardiac outcomes in pregnant in women with heart disease Four predictors of maternal cardiac complications were identified and incorporated into a risk index, the CARPREG risk score References Thorne S, Nelson-Piercy C, MacGregor A, et al Pregnancy and contraception in heart disease and pulmonary arterial hypertension J Fam Plann Reprod Health Care 2006;32:75–81 Silversides CK, Sermer M, Siu SC Choosing the best contraceptive method for the adult with congenital heart disease Curr Cardiol Rep 2009;11:298–305 Greutmann M, Silversides CK The ROPAC registry: a multicentre collaboration on pregnancy outcomes in women with heart disease Eur Heart J 2013;34:634–635 Siu SC, Sermer M, Colman JM, et al Prospective multicenter study of pregnancy outcomes in women with heart disease Circulation 2001;104:515–521 Silversides CK, Grewal J, Mason J, et al Pregnancy outcomes in women with heart disease: the CARPREG II study J Am Coll Cardiol 2018;71(21):2419–2430 Khairy P, Ouyang DW, Fernandes SM, et al Pregnancy outcomes in women with congenital heart disease Circulation 2006;113:517–524 Drenthen W, Boersma E, Balci A, et al