explicit in 2004 when an expert panel published revised criteria for diagnosing and treating children with suspected KD Fever is probably the most consistent manifestation of KD It reflects the elevated levels of proinflammatory cytokines (e.g., TNF-α, IL-1), which are also believed to mediate the underlying vascular inflammation A diagnosis of KD should be considered in all children with prolonged, unexplained fever, irritability, and laboratory signs of inflammation, especially in the presence of mucocutaneous inflammation Conversely, the diagnosis must be suspect in the absence of fever TABLE 101.16 DIAGNOSTIC CRITERIA FOR KAWASAKI DISEASE Fever ≥5 days unresponsive to antibiotics If the fever disappears because of intravenous gamma-globulin therapy before the fifth day of illness, a fever of