TABLE 39.2 RECOMMENDED THERAPEUTIC AGENTS FOR INGUINAL INFECTIONS Infection Antibiotic/antiviral agent Skin and soft tissue infections First-generation cephalosporin according to local sensitives Clindamycin or trimethoprim/sulfamethoxazole for MRSA coverage Streptomycin or gentamycin, fluoroquinolones, tetracyclines Gentamycin or ciprofloxacin for mild disease Acyclovir a Penicillin G benzathine Azithromycin or ceftriaxone Yersinia pestis (plague) Ulceroglandular tularemia HSV Syphilis Haemophilus ducreyi (chancroid) Lymphogranuloma Doxycycline or erythromycin b venereum (Chlamydia trachomatis ) Granuloma inguinale Azithromycin, doxycycline, ciprofloxacin (Klebsiella granulomatis ) trimethroprim/sulfamethoxazole, or erythromycin a To shorten symptoms of primary disease; therapy cannot affect frequency/severity of recurrence treatment course b Three-week