Tài liệu Pharmaceutical Coating Technology (Part 3) pdf

... steps involved in sugar coating are covered in som e detail, i.e. sealing, subcoating, smoothing, colour coating, polishing and printing. In the section dealing with subcoating several suitable ... the dosage form. 3.1 INTRODUCTION The pharmaceutical process of sugar coating remains a widely practised technology despite the interest arising from film -coating techniques since...

Ngày tải lên: 24/12/2013, 18:15

... practice in pharmaceutical coating, the ability of the coating equipment to evaporate the solvent satisfactorily may be overcome and the product overwetted, resulting in poor-quality coatings. ... granule or multiparticulate film coating to date, since those available either have difficulty in coping with the flow rates required for either organic or aqueous film coating, produce d...

Ngày tải lên: 24/12/2013, 18:15

... designed for aqueous film coating in a side-vented pan. A comparison is made of energy requirements of a column -coating system and a coating pan. All the major operational coating parameters can ... Q=GC p .ΔT=9010×0.25×4.2×40 Table 6.3 Energy balance: comparison of a 1500 mm diameter coating pan and a 450 mm fluidized bed coating column 1500 mm coating pan 450 mm column...

Ngày tải lên: 24/12/2013, 18:15

... is expensive and is generally the reason for pharmaceutical companies to convert coating formulations to aqueous systems or formulate aqueous coating for all new products. Where this is not ... moisture from the core during the coating process. Weighing the tablets before and after coating will not, therefore, give an absolute measure of the weight of coating deposited. Vario...

Ngày tải lên: 22/01/2014, 00:20

... automated pharmaceutical dispensary. materials to the production area for preparation of the powder mix ready for tablet core manufacture and raw materials for the preparation of the coating. ... Lumsden, B. (1982) Industrial Powder Technology Conf., London, 24–25 November. Morley, R.E. (1984) The rate of control in automation trends and perspectives Pharmaceutical Engineering ,...

Ngày tải lên: 22/01/2014, 00:20

... the coating pan. A system for spraying film for testing within an actual coating pan was described by Porter (1980) who placed a vinyl-covered card inside a coating pan during an actual coating ... 298 commonly used methods to examine pharmaceutical film -coating systems. Presented below is a very brief introduction to the application of thermal analysis in the study of pharmac...

Ngày tải lên: 22/01/2014, 00:20

... • Sugar coating • Film coating • Particulate/pellet coating • Compression coating. Page i Pharmaceutical Coating Technology Page 3 one hundred of these pans to be installed in a coating department. ... The coating process Graham C.Cole Summary 170 7.1 Process development of aqueous film coating 170 7.2 Theoretical considerations of film coating 172 7.3 The mec...

Ngày tải lên: 24/12/2013, 18:15

... POLYMERS REFERENCES Abdul-Razzak, M.H. (19 83) Ph. D Thesis, C.N.A. A., Leicester Polytechnic. Anon. (1988) Manufacturing Chem. June, 33, 35. Anon. (19 93) Colour Kit and International Pharmaceutical Colour Regulation ... E.F.T. (1988) Int. J. Pharm. 48, 63–77. Handbook of Pharmaceutical Excipients (1986) American Pharmaceutical Association, Washington and Royal Pharmaceutica...

Ngày tải lên: 24/12/2013, 18:15

... process of film coating of pharmaceutical solid dosage forms, one cannot escape a consideration of surface aspects relating to the wetting of granule, pellet or tablet cores by the coating solution ... to produce much more efficient and elegant films. Film coatings are invariably applied in the pharmaceutical industry by spraying a coating solution or suspension onto the surface...

Ngày tải lên: 24/12/2013, 18:15

... 170 7 The coating process Graham C.Cole SUMMARY In recent years tablet coating has undergone several fundamental changes. The original sugar -coating technique has been largely replaced by film -coating ... parts of the equipment can provide a reduction in the overall coating cycle. 7.1 PROCESS DEVELOPMENT OF AQUEOUS FILM COATING Coating of tablets and pills is one of the oldest...

Ngày tải lên: 22/01/2014, 00:20