Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours pot

... FEBS REVIEW ARTICLE Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours S. Toffoli and C. Michiels Laboratory of Biochemistry and Cellular Biology ... 3374–3378. 101 Kanaan A, Farahani R, Douglas RM, Lamanna JC & Haddad GG (2006) Effect of chronic continuous or intermittent hypoxia and reoxygenation...

Ngày tải lên: 30/03/2014, 04:20

... contains two arginine ⁄ glycine-rich (RGG) motifs that are characteristic of RNA-binding proteins, and an alanine-rich carboxy-terminal sequence that could be involved in protein–protein interactions. Interestingly, ... homologs are poly (A) polymerases. Proc Natl Acad Sci USA 101, 4407–4412. 18 Nakanishi T, Kubota H, Ishibashi N, Kumagai S, Watanabe H, Yamashita M, Kashiwabara S, Miya...

Ngày tải lên: 07/03/2014, 05:20

... statistical breadth and convenience of automatic expansion. Fortunately, statistical corpus analysis is an ob- vious area of overlap for IR and FLP. Distribu- tional analyses of large corpora ... viewed as stars). Mason (2004) shows how statistical analysis can automatically detect and extract conventional metaphors from corpora, though creative meta- phors still remain a tant...

Ngày tải lên: 07/03/2014, 22:20

... M & Rahmani Z (2005) Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK 1A) interacts with the phytanoyl-CoA alpha- hydroxylase associated protein 1 (PAHX-AP1), a brain specific ... Contestabile A, Fila T, Ceccarelli C, Bonasoni P, Bonapace L, Santini D, Bartesaghi R & Ciani E (2007) Cell cycle alteration and decreased cell prolifer- ation in the hippoc...

Ngày tải lên: 22/03/2014, 16:21

... proliferation [55]. The assess- ment of cellular proliferation in histological material is a valuable component of conventional histopathologi- cal analysis and may be of major prognostic import- ance ... proliferating (log) and serum-starved T98G cells (A) and human embryonic fibroblasts (HEF) (C). (B) Immunoblot analysis of DNA polymerase d p125 and p50 subunits, PCNA...

Ngày tải lên: 19/02/2014, 00:20

... Ac-YVAD-AMC is a substrate for caspase 1; Ac-IETD-AMC is a substrate for caspase 8 and 10; Ac-LEHD-AMC is a substrate for caspases 2, 4, 5 and 9. Ac-DVPD-AMC, Ac-DPSD-AMC and Ac-ESQD-AMC are tetra peptide ... caspases and KIPase have the potential to be key regulators of p27 KIP1 and thus the mammalian cell cycle. Both the abundance and function of p27 KIP1 are...

Ngày tải lên: 19/02/2014, 13:20

... TAT ATG T Weak 3 aa 2 ⁄ 4 55067 TCA ATG C Weak 58 aa 3 33 39% 60929 60933 60939 GTA ATG C TGC ATG T TCC ATG G G Adequate Weak Adequate 13 aa 33 aa 31 aa 3¢ 76 49% – 4¢ 56 61% 61041 GGA ATG T Adequate ... membrane or with the membranes of intracellular organelles although they lack a transmembrane domain. They are attached to the cytoplasmic face of the membranes via palmitoyl anchors [1...

Ngày tải lên: 19/02/2014, 17:20

... (Fig. 5A, lane 1). These data strongly indicate that SDF-1 induces a rapid and significant increase in the tyrosine phosphorylation of SD-4 on HeLa cells and that a physical association of tyrosine ... (2002) Interaction of the CC-chemokine RANTES with glycosaminogly- cans activates a p44 ⁄ p42 mitogen-activated protein kin- ase-dependent signaling pathway and enhances huma...

Ngày tải lên: 16/03/2014, 18:20

... performed TLC analysis of chromophore standards against an organic extract isolated from the dimeric Cyt b 6 f complex for chromophore identification (Fig. 4). In parallel, the standards and pigment extracts ... show in etio- plasts that a Cyt b 6 f complex can be isolated with a molecular mass and subunit composition indistinguish- able from dimeric Cyt b 6 f isolated from chlor...

Ngày tải lên: 23/03/2014, 07:20

... Bacterial IscU is a well folded and functional single domain protein Salvatore Adinolfi 1 , Francesca Rizzo 1 , Laura Masino 1 , Margie Nair 1 , Stephen R. Martin 1 , Annalisa Pastore 1 and ... studies hint at a mechanism for prokaryotes in which IscS and IscU play a central role [3,4]. This mechanism however, is also preserved in eukaryotic cells. IscS is analogous to Ni...

Ngày tải lên: 23/03/2014, 12:20