... promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated transcript. Taken together, these findingsprovide a compelling argument for the role for malo-nyl-CoA in regulating ... expenditure. Thus, insulin, leptinand ghrelin, as well as other hormones ⁄ cytokines,interact with their cognate receptors on neurons within the CNS that project to higher brain centers and to peripheral ... higherorganisms, this involves storing energy as fat duringperiods of an abundant food supply to hedge againstperiods of food shortage. Today, humans have pushedstorage too far, to the point of widespread...