Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... promoting an increase in proopiomelanocortin and cocaine and amphetamine regulated transcript. Taken together, these findings provide a compelling argument for the role for malo- nyl-CoA in regulating ... and certain amino acids [16]. A linkage between fatty acid synthesis in the CNS and feeding behavior was uncovered with the finding that systemic or intracerebroventricular admin...

Ngày tải lên: 14/02/2014, 22:20

... were raised in rabbits against a GST-War1p fusion protein containing 294 amino acids of the C-terminal part of War1p (amino acids 650– 944) fused in- frame to the C-terminus of GST. The gene fusion ... DNA-binding zinc cluster at the N-terminus, whereas the acidic activation domain is usually present at the C-terminus. The mid- dle homology region (MHR) bridging the D...

Ngày tải lên: 19/02/2014, 00:20

... defining the set of items that have ever been the actor in a flight. Their definition is solely within NIKL using the QUA link [14], which is exactly the set of fillers of a slot. While having ... expressions in inten- sional logic. 3 4. Use of the Taxonomy in Janus By domain mode/we mean the set of axioms en- coded in NIKL regarding the constants. The...

Ngày tải lên: 21/02/2014, 20:20

... meanings). 2. the meaning of the rules (rule meanings). In Montague Grammar these meanings are ex- pressed in intensional logic. In the Rosetta system the meanings of rules and basic expressions ... for the compositional and the analytical definition of a language. This is proved by the formal definitions in subsection 6.2. The third problem concerned the...

Ngày tải lên: 22/02/2014, 10:20

... obese mice In order to gain insights into the potential biologically relevant role of miR-27 in the regulation of adipose tis- sue functions in vivo, we examined the expression of miR-27 in the genetically ... together, these results illustrate a critical and specific role of miR-27 in the regulation of adipogenic differentiation. miR-27 prevents the inducti...

Ngày tải lên: 18/02/2014, 08:20

... thus blocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing ... hypothesize that the cytotoxic activity of the latter monomers was due to the presence in these proteins of disulfide bonds, with their potential chemical ins...

Ngày tải lên: 20/02/2014, 11:20

... obtained by other groups who also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutational analysis [35] and structural analysis of the plant defensin Rs-AFP1 ... molecule comprising Ôresidues in the protruding domain consisting of the type VI b-turn and the first part of b-strand 3Õ (i.e. the b-hairpin loop and part...

Ngày tải lên: 20/02/2014, 11:20

... disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The processes are independent of the know- ledge ... affected. The study includes off-line picture naming which forces use of articles in all of the above contexts, as well as on-line production of these morph...

Ngày tải lên: 21/02/2014, 20:20

... near the N- and C-termini of the linkers: this suggests that a mobile connection with both the catalytic domain and the binding module is required for the function of the nanomachine. Furthermore, ... covering the face of the aromatic ring [25]. Alternatively, the ring may sterically disfavor extensive bending in this region, which could result in unwanted interac...

Ngày tải lên: 14/02/2014, 18:20

... Yer- sinia, the increased synthesis of LcrV triggered by the activation of the system leads to the titration of LcrG, which binds LcrV in a 1 : 1 complex. In turn, this results in a release of the ... by the sug- gestion that pH sensing by Salmonella involves modi- fications in the assembly of the translocon, which affect the pH gradient within the needle,...

Ngày tải lên: 14/02/2014, 22:20