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This PhD study aimed to understand the epidemiology of Clostridium difficile in Vietnam. Human and environmental samples in two provinces in Vietnam were collected. RT 012 and RT 017 were found to be the most prevalent strains in humans. C. difficile RTs 001 and QX 574 was isolated from pig environment soils, hospital beds, and hospital soils. All isolates were susceptible to vancomycin, metronidazole, and fidaxomicin, but showed varying resistance to other antimicrobials. A recent shared ancestry between eight Vietnamese C. difficile strains, highlighting the possible transmission of C. difficile between the environment and humans. One Health approach is required.
CLOSTRIDIUM DIFFICILE IN VIETNAM Peng An Khun (MD, MiInfDis) THE UNIVERSITY OF WESTERN AUSTRALIA This thesis is presented for the degree of Doctor of Philosophy The University of Western Australia Microbiology and Immunology School of Biomedical Sciences 2024 10.26182/q9d0-8m45 https://api.research-repository.uwa.edu.au/ws/portalfiles/portal/330959107/THESIS DOCTOR OF PHILOSOPHY _- KHUN Peng An _ - 2024.pdf -