... membranecompared with when it is still in the ER [5]. This is con-sistent with the theory that it is stably anchored at the nuclear membrane through its interaction with lamin A ⁄ C. Interestingly, an autosomal ... R, Ogawa M, Kurano Y, Kawada J,Okada R, Hayashi YK, Tsukahara T & Arahata K(1996) Emerin deficiency at the nuclear membrane in patients with Emery–Dreifuss muscular dystrophy. NatGenet 12, ... AD-EDMD patients [14] and to the ER in the LMNA knock-outmouse [15], confirming that retention of emerin at theinner nuclear membrane is, at least partly, through itsinteraction with lamin A ⁄ C.The...