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Báo cáo y học: "The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosus" potx

Báo cáo y học:

Báo cáo y học: " Dysfunctional interferon-α production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus" doc

... GAC TCA GGT TT-3'Reverse: 5'-TGC TTC TGA C G GTA TGT ATT A- 3'MyD88s Forward: 5'-CGG CAA CTG GAG ACA CAA G-3'Reverse: 5'-TCT GGA AGT CAC ATT CCT TGC-3'IRAK-M ... 5'-AGC CCA TAG CAT TCG TCT CAG-3'IFIT1 Forward: 5'-CTC CTT GGG TTC GTC TAC AAA TTG-3'Reverse: 5'-AGT CAG CAG CCA GTC TCA G-3'PRKR Forward: 5'-CTT CCA TCT ... GTA CAG GTC TTT G-3'TLR9 Forward: 5'-GTG CCC CAC TTC TCC ATG-3'Reverse: 5'-GGC ACA GTC ATG ATG TTG TTG-3'IFI44 Forward: 5'-CTC GGT GGT TAG CAA TTA TTC CTC-3'Reverse:...
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báo cáo hóa học:

báo cáo hóa học: " The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson''''s disease" docx

... data, performed dataanalysis and drafted the manuscript.PAF participated in collecting posturographic data,assisted in data analysis and in drafting the manuscript.GBJ participated in the ... difference in sway parameters among thosethat could cope with the perturbations.The aim of the present study was to investigate the effectof STN stimulation alone. In daily life, the patients arehowever ... STNstimulation.Competing interestsThe authors declare that they have no competing interests.Authors' contributionsMN participated in the design of the study, recruited patients, managed acquisition of data,...
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Báo cáo y học:

Báo cáo y học: "Carotid intima-media thickness and endothelial function: useful surrogate markers for establishing cardiovascular risk in patients with inflammatory rheumatic disease" pdf

... in 47 patients with RA withoutclinically evident cardiovascular disease at the time ofevaluation by carotid ultrasonography. In our study carotidIMT, categorized in quartiles, was strongly ... with rheumatoid arthritis (RA). They statethat it remains an open question, because no long-termstudies have documented such an association in patients with RA. We are pleased to provide the ... explainwhy GCA mortality in very distant regions (such asRochester, Minnesota, USA and Lugo, north west Spain) is comparable to that observed in the general population of thesame age [4]. In this...
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Báo cáo y học:

Báo cáo y học: "Impact of concomitant aortic regurgitation on long-term outcome after surgical aortic valve replacement in patients with severe aortic stenosis" potx

... survi-val was tested using a univariate and multivariate analy-sis. Variables with p < 0,1 in univariate were included in multivariate analysis. A p < 0,05 in multivariate analysiswas considered ... hypertrophy in patients with AS andcoexisting significant AR, in relation to patients with isolated AS, was also noted in earlier reports [5,6].There is ongoing controversy with respect to theimpact ... of the degree of associated AR [10]. Someauthors separately analyzed patients with pure AS and patients with AS and mild or moderate, [11] while otherauthors analyzed only patients with AS and...
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Báo cáo y học:

Báo cáo y học: "The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosus" potx

... hnRNP -A2 in patients with RA [27]. We observed thatapproximately half of the RA patients harbor T cells againsthnRNP -A2 . In accordance with the perception of RA as aninflammatory, Th1 type systemic ... hnRNP -A2 may constitute an important T cell autoantigen in patients with SLE, indicating a potentialrole for it in the pathogenesis of this disorder.Materials and methods Patients and controlsPeripheral ... 4Research articleThe spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP -A2 ) is a major T cell autoantigen in patients with systemic lupus erythematosusRuth Fritsch-Stork1,...
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Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt

Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt

... chromatinby phosphorylation by a kinase(s) in a syntheticphase egg cytosolChromatin binding of beads bearing GST–NK was incr-eased by pretreatment w ith a synthetic phase egg cytosolfraction ... ith anti-(human LBR) Ig, participates in thetargeting [37]. Therefore, the participation o f LBR in thetargeting of nuclear membranes to chromatin may vary a little from system to system a nd/or ... o f treatment with a m itoticphase cytosol fraction (Fig. 5B). These r esults show thatthe affinity of the N-terminal portion of LBR andchromatin increases in a synthetic phase extract anddecreases...
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Báo cáo Y học: The Saccharomyces cerevisiae type 2A protein phosphatase Pph22p is biochemically different from mammalian PP2A potx

Báo cáo Y học: The Saccharomyces cerevisiae type 2A protein phosphatase Pph22p is biochemically different from mammalian PP2A potx

... amino acids) we used: sense primer:5¢-CGGGATCCACCATGCATCATCATCATCATCATCATCATCTTGACCAATGGATTGAGCATTTG-3¢(BamHI site underlined, 8 · His-tag bold) and antisense:5¢-CGGAATTCTTACTGATTTATATTTGTATTGGTCAG-3¢ ... using a standard protocol. Thefollowing primers were used: sense (1), 5¢-CGGGATCCACCATGCATCATCATCATCATCATCATCATGATATGGAAATTGATGACCCTATG-3¢ (BamHI site under-lined, 8 · His-tag bold) and antisense ... phosphatase activa-tor (PTPA), a protein isolated from mammalian tissuebased on its ability to stimulate PP 2A activity againstphosphotyrosine residues, are present in the budding yeastgenome...
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Báo cáo Y học: The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells potx

Báo cáo Y học: The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells potx

... 5¢-TGTGCAGCCCATAAGGACACACAG-3¢ (Axl,sense)and5¢-ATGGTGGCTGTGCGGGAGGTGGTGA-3¢ (Axl, antisense), which generated a 595-bp Axl PCR product; 5¢-TGTCCAAGGGTGTACATATCAACAT-3¢ (Mer,sense)and5¢-AGCCGAGGATGATGAACATAGAGT-3¢ ... mutatedbases at the middle (in italic) and 15 complementary bases atthe 5¢ and 3¢ ends. The mutation primers MP-B: 5¢-GGAGTACTAACCCTGGCCTAGCAAAATAGGCTGTCCC-3¢ and MP-C: 5¢-GGAGTACTAACCCTGGCCTTTATGTTTTTGGCGTCTTCCA-3¢ ... to interactphysically with Sp1 to activate the human DNA polymer-ase a promoter and to exert a slightly greater than additiveeffect on the mouse thymidylate synthetase promoter; bothof these...
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Báo cáo Y học: The Emery–Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A pptx

Báo cáo Y học: The Emery–Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A pptx

... membranecompared with when it is still in the ER [5]. This is con-sistent with the theory that it is stably anchored at the nuclear membrane through its interaction with lamin A ⁄ C. Interestingly, an autosomal ... R, Ogawa M, Kurano Y, Kawada J,Okada R, Hayashi YK, Tsukahara T & Arahata K(1996) Emerin deficiency at the nuclear membrane in patients with Emery–Dreifuss muscular dystrophy. NatGenet 12, ... AD-EDMD patients [14] and to the ER in the LMNA knock-outmouse [15], confirming that retention of emerin at theinner nuclear membrane is, at least partly, through itsinteraction with lamin A ⁄ C.The...
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Báo cáo y học:

Báo cáo y học: "The anti-vaccination movement and resistance to allergen-immunotherapy: a guide for clinical allergists" ppt

... employs ther apeutic s that aresimilar to, yet distinct from, vaccines. Indeed, this articlewill demonstrate that propagandist anti-vaccinationwebsites have started transposing vaccine-fears ... both contain adju-vants and preservatives), as well as not hesitate to statethat the risk of adverse reactions associated with IT is greater than that of vaccination (though both haveexcellent ... anti-vaccination rhetoric.Clinicians need to be aware of how patients maymistakenly think they are being forced or coerc ed intotreatment and be ready to assert that patients are free tostop treatment...
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